Peripheral versus Central Index of Metabolic Dysfunction and Associations with Clinical and Pathological Outcomes in Alzheimer's Disease.

@article{McLimans2017PeripheralVC,
  title={Peripheral versus Central Index of Metabolic Dysfunction and Associations with Clinical and Pathological Outcomes in Alzheimer's Disease.},
  author={Kelsey E McLimans and Joseph L Webb and Vellareddy Anantharam and Anumantha G Kanthasamy and Auriel A. Willette},
  journal={Journal of Alzheimer's disease : JAD},
  year={2017},
  volume={60 4},
  pages={
          1313-1324
        }
}
BACKGROUND/OBJECTIVE Insulin-like growth factor binding protein 2 (IGFBP-2) regulates blood glucose levels, facilitates hippocampal synaptic plasticity and may have a predictive value for Alzheimer's disease (AD) diagnosis. METHODS IGFBP-2 levels were studied in plasma in 566 subjects and in cerebrospinal fluid (CSF) in 245 subjects across the AD spectrum from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Variants in the IGFBP-2 gene were examined. Linear mixed modeling in SPSS… CONTINUE READING