Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease.

@article{Sangkatumvong2011PeripheralVA,
  title={Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease.},
  author={Suvimol Sangkatumvong and Michael C. K. Khoo and Roberta M. Kato and Jon A Detterich and Adam Bush and Thomas G. Keens and Herbert J. Meiselman and John C. Wood and Thomas D. Coates},
  journal={American journal of respiratory and critical care medicine},
  year={2011},
  volume={184 4},
  pages={
          474-81
        }
}
RATIONALE Sickle cell disease is an inherited blood disorder characterized by vasoocclusive crises. Although hypoxia and pulmonary disease are known risk factors for these crises, the mechanisms that initiate vasoocclusive events are not well known. OBJECTIVES To study the relationship between transient hypoxia, respiration, and microvascular blood flow in patients with sickle cell. METHODS We established a protocol that mimics nighttime hypoxic episodes and measured microvascular blood… CONTINUE READING

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Sigh induces a decrease in blood flow and increase in spectral density of blood flow oscillations in sickle cell disease [abstract

  • RM Kato, S Sangkatumvong, +6 authors TD. Coates
  • Am J Respir Crit Care Med
  • 2010

Decrease in microvascular blood flow in sickle cell anemia is triggered by autonomic signals and not directly by hypoxia : a new hypothesis for sickle crisis [ abstract ]

  • S Sangkatumvong, R Kato, +4 authors TD Coates
  • Presented at the 51 st ASH Annual Meeting and…
  • 2009

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