Peripheral vascular remodeling in chronic heart failure: clinical relevance and new conceptualization of its mechanisms.

@article{Nakamura1999PeripheralVR,
  title={Peripheral vascular remodeling in chronic heart failure: clinical relevance and new conceptualization of its mechanisms.},
  author={Mari Nakamura},
  journal={Journal of cardiac failure},
  year={1999},
  volume={5 2},
  pages={127-38}
}
Increased peripheral vascular tone is a critical factor in the deterioration of clinical stage and symptoms in chronic congestive heart failure (CHF) because of increased cardiac afterload and decreased nutritive skeletal muscle blood flow. Endothelial function as represented by nitric oxide (NO) production shows significant attenuation with the progression of clinical severity of CHF as determined by New York Heart Association class and exercise capacity parameters. This endothelial… CONTINUE READING
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