Peripheral-type benzodiazepine receptors are highly concentrated in mitochondrial membranes of rat testicular interstitial cells.

@article{Calvo1990PeripheraltypeBR,
  title={Peripheral-type benzodiazepine receptors are highly concentrated in mitochondrial membranes of rat testicular interstitial cells.},
  author={Daniel J Calvo and Monica Nora Ritta and Ricardo Sa{\'u}l Calandra and Jorge H Medina},
  journal={Neuroendocrinology},
  year={1990},
  volume={52 4},
  pages={
          350-3
        }
}
The binding of 3H-RO 5-4864 to the peripheral-type benzodiazepine receptors (PBZDR) in rat testicular interstitial cells (TIC) was characterized. The binding was saturable, reversible and showed a single high-affinity (Kd = 5.02 +/- 0.86 nM) class of binding sites. The maximal binding capacity (Bmax) in crude mitochondrial fractions (77.6 +/- 9.1 pmol/mg protein) represents the highest density of PBZDR in tissues thus far studied. In comparison with the crude mitochondrial fraction the… CONTINUE READING
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