Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.

@article{Hauet2005PeripheraltypeBR,
  title={Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.},
  author={Thierry Hauet and Z Yao and Himangshu S. Bose and Christopher T Wall and Zeqiu Han and Wenping Li and Dale Buchanan Hales and Walter Miller and Martine Culty and Vassilios Papadopoulos},
  journal={Molecular endocrinology},
  year={2005},
  volume={19 2},
  pages={540-54}
}
Hormone-induced steroid biosynthesis begins with the transfer of cholesterol from intracellular stores into mitochondria. Steroidogenic acute regulatory protein (StAR) and peripheral-type benzodiazepine receptor (PBR) have been implicated in this rate-determining step of steroidogenesis. MA-10 mouse Leydig tumor cells were treated with and without oligodeoxynucleotides (ODNs) antisense to PBR and StAR followed by treatment with saturating concentrations of human choriogonadotropin. Treatment… CONTINUE READING
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