Peripheral-type benzodiazepine binding in Alzheimer disease.

  title={Peripheral-type benzodiazepine binding in Alzheimer disease.},
  author={E. G. McGeer P. L. McGeer and Edith A Singh and Patrick L. Mcgeer},
  journal={Alzheimer disease and associated disorders},
  volume={2 4},
Peripheral-type benzodiazepine binding of [3H]Ro5-4864 at one, non-saturating concentration and activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in 7 cortical areas from postmortem brains of 18 patients with Alzheimer disease (AD), 12 age-matched controls, and 15 miscellaneous neurological cases. None of the chemical measures showed significant correlation with age, sex, or postmortem delay. As expected, ChAT and AChE activities were closely… CONTINUE READING


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