Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice

@inproceedings{Dong2016PeripheralSW,
  title={Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice},
  author={Yuanlin Dong and Zhipeng Xu and Lining Huang and Yiying Zhang and Zhongcong Xie},
  booktitle={Medical gas research},
  year={2016}
}
Post-operative cognitive dysfunction (POCD) is associated with morbidity, mortality and increased cost of medical care. However, the neuropathogenesis and targeted interventions of POCD remain largely to be determined. We have found that the peripheral surgical wounding induces an age-dependent Aβ accumulation, neuroinflammation and cognitive impairment in… CONTINUE READING