Peripheral progesterone (P) levels and endometrial response to various dosages of vaginally administered P in estrogen-primed women.

@article{Pasquale1997PeripheralP,
  title={Peripheral progesterone (P) levels and endometrial response to various dosages of vaginally administered P in estrogen-primed women.},
  author={Somma Pasquale and R G Foldesy and Jeffrey P Levine and Gloria Ann Bachmann and Richard Edgar Blackwell},
  journal={Fertility and sterility},
  year={1997},
  volume={68 5},
  pages={810-5}
}
OBJECTIVE To compare the pharmacokinetics and pharmacodynamics of 100 mg/d, 200 mg/d, and 400 mg/d (200 mg two times per day) of P administered vaginally for 14 days to estrogen-primed postmenopausal women. DESIGN Randomized, open-label, three-way crossover study. SETTING Two university-based investigative sites. PATIENT(S) Twenty healthy postmenopausal women with histologically normal endometria. INTERVENTION(S) Oral 17 beta-E2 was given each day of a 28-day cycle; a P vaginal… CONTINUE READING