Peripheral orphanin FQ/nociceptin analgesia in the mouse.

@article{Kolesnikov1999PeripheralOF,
  title={Peripheral orphanin FQ/nociceptin analgesia in the mouse.},
  author={Yuri Alexeyevich Kolesnikov and Gavril W Pasternak},
  journal={Life sciences},
  year={1999},
  volume={64 22},
  pages={2021-8}
}
Orphanin FQ/Nociceptin (OFQ/N) administered peripherally was an effective analgesic in the tailflick test in mice (ED50 16.3 microg). It had a peak effect at 5 min and lasted up to 30 min. The kappa3 analgesic naloxone benzoylhydrazone was also active peripherally (ED50 3.8 microg). The analgesic actions of both agents were blocked by naloxone. Neither OFQ/N(1-11) nor OFQ/N(1-7) had appreciable peripheral activity. Antisense mapping both compounds against the murine orphan opioid receptor (KOR… CONTINUE READING