Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.

@article{Stein1989PeripheralOR,
  title={Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.},
  author={Christoph Stein and M. J. Millan and T. S. Shippenberg and Karlheinz Peter and A. Herz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={248 3},
  pages={1269-75}
}
This study examined a possible peripheral site of action of opioids in the modulation of the response to noxious pressure on inflamed tissue. Rats developed a unilateral localized inflammation upon injection of Freund's complete adjuvant into one hindpaw. 4-6 days after inoculation, intraplantar administration of mu, delta and kappa selective agonists [D-Ala2,N-methyl-Phe4,Gly-ol5]-en-kephalin (1 micrograms), [D-Pen2,5]-enkephalin (40 micrograms) and U-50, 488H (50 micrograms) produced marked… CONTINUE READING
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