Peripheral neuropathy response to erythropoietin in type 2 diabetic patients with mild to moderate renal failure

  title={Peripheral neuropathy response to erythropoietin in type 2 diabetic patients with mild to moderate renal failure},
  author={Mahshid S Hosseini-Zare and S. Dashti-Khavidaki and M. Mahdavi-Mazdeh and F. Ahmadi and S. Akrami},
  journal={Clinical Neurology and Neurosurgery},
This study assessed the added effect of 6 months of erythropoietin (EPO) administration in patients suffering from diabetic neuropathy with mild to moderate chronic kidney disease (CKD) managed with gabapentin. Twenty diabetic patients with mild to moderate CKD were included; 12 in gabapentin and 8 in EPO+gabapentin group. The subjects underwent nerve conduction studies (NCS) at the initiation of the investigation and after 6-month treatment. NCS were made in deep and superficial peroneal… Expand
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Subcutaneous EPO therapy improved motor polyneuropathy in uremic patients, especially non-diabetic individuals, and this non-hematopoietic effect may be related to some direct action through EPO receptors on peripheral neurons. Expand
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Accelerated neuropathy of renal failure.
This partly reversible acute uremic neuropathy, which is probably caused by the metabolic disturbances of end-stage renal failure, simulates Guillain-Barré syndrome or chronic inflammatory demyelinating polyneuropathy and may be complicated by diabetic neuropathy. Expand
Inappropriately low erythropoietin response for the degree of anemia in patients with noninsulin-dependent diabetes mellitus
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  • C. Bolton
  • Medicine
  • The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • 1980
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