Peripheral neuropathy induced by 2',3'-dideoxycytidine. A rabbit model of 2',3'-dideoxycytidine neurotoxicity.

@article{Anderson1992PeripheralNI,
  title={Peripheral neuropathy induced by 2',3'-dideoxycytidine. A rabbit model of 2',3'-dideoxycytidine neurotoxicity.},
  author={Timothy D. Anderson and Alberto Davidovich and Ramiro Arceo and C Brosnan and Joseph Arezzo and Herbert Schaumburg},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1992},
  volume={66 1},
  pages={
          63-74
        }
}
The nucleoside analog 2',3'-dideoxycytidine (ddC) is a potent inhibitor of the reverse transcriptase of human immunodeficiency virus and a DNA chain terminator. In clinical trials in patients with acquired immunodeficiency syndrome, ddC treatment has been associated with a dose-limiting and dose-dependent, painful, sensorimotor peripheral neuropathy. In search of an animal model for ddC-induced neurotoxicity we studied 36 New Zealand White rabbits (3 males/3 females/group) given 0, 10, 50, 100… CONTINUE READING

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