Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies

@article{NobileOrazio1992PeripheralNI,
  title={Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies},
  author={E. Nobile-Orazio and S. Barbieri and L. Baldini and P. Marmiroli and M. Carpo and S. Premoselli and E. Manfredini and G. Scarlato},
  journal={Acta Neurologica Scandinavica},
  year={1992},
  volume={85}
}
  • E. Nobile-Orazio, S. Barbieri, +5 authors G. Scarlato
  • Published 1992
  • Medicine
  • Acta Neurologica Scandinavica
  • In an unselected series of patients with monoclonal gammopathy of undetermined significance (MGUS) we found neuropathy in 2 of 34 patients with IgG (6%), 2 of 14 with IgA (14%), and 8 of 26 with IgM MGUS (31%). The neuropathy was subclinical in 6 patients (1 IgG, 1 IgA, and 4 IgM). Patients with IgG or IgA MGUS had a prominent motor impairment with electrophysiologic and morphologic findings suggestive of predominant axonal degeneration. No deposit of the M‐protein in sural nerve and no… CONTINUE READING
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