Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies

@article{NobileOrazio1992PeripheralNI,
  title={Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies},
  author={Eduardo Nobile‐Orazio and Sergio Barbieri and Luca Baldini and Paola Marmiroli and Marinella Carpo and S. Premoselli and Emanuela Manfredini and Guglielmo Scarlato},
  journal={Acta Neurologica Scandinavica},
  year={1992},
  volume={85}
}
In an unselected series of patients with monoclonal gammopathy of undetermined significance (MGUS) we found neuropathy in 2 of 34 patients with IgG (6%), 2 of 14 with IgA (14%), and 8 of 26 with IgM MGUS (31%). The neuropathy was subclinical in 6 patients (1 IgG, 1 IgA, and 4 IgM). Patients with IgG or IgA MGUS had a prominent motor impairment with electrophysiologic and morphologic findings suggestive of predominant axonal degeneration. No deposit of the M‐protein in sural nerve and no… 
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Axonal neuropathy associated with monoclonal gammopathy of undetermined significance
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A case of mild axonal sensory neuropathy associated with anti–MAG-negative IgM-j-MGUS that progressed to severe mononeuritis multiplex in the setting of accelerated immune complex deposition after rituximab is reported.
Polyneuropathy associated with IgG/IgA monoclonal gammopathy: a clinical and electrophysiological study of 15 cases
TLDR
Clinical and electrophysiological studies clearly showed that the demyelinating pattern was more heterogeneous in IgG/IgA‐DP than in IgM‐DP, which is similar to classic CIDP, and axonal polyneuropathy, in which the pathogenic role of the MG remains elusive.
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TLDR
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Neuropathies associated with monoclonal gammopathies
Frequency and clinical correlates of anti–neural IgM antibodies in neuropathy associated with IgM monoclonal gammopathy
TLDR
The frequent occurrence of anti–neural IgM antibodies in neuropathy associated with IgM gammopathy, and their frequent, though not constant association with similar neuropathy features, support their possible pathogenetic role in the neuropathy.
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References

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TLDR
Three patients with chronic sensorimotor polyneuropathy associated with plasma cell dyscrasia and monoclonal gammopathies and patients' serum was injected intraneurally into rat sciatic nerves to investigate the role the paraproteins might play in the pathogenesis of the neuropathy, and studies employing an in vivo bioassay technique failed to establish antimyelin activity of monOClonal immunoglobulin sera.
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TLDR
Recent advances have been made in characterizing the autoantibody activity of M-proteins and correlating antigenic specificity with the type of neuropathy present, in elucidating the effector mechanisms responsible for causing nerve injury, and in understanding the causes for the aberrant immune response.
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TLDR
Among patients with chronic idiopathic nonfamilial polyneuropathy studied 3 to 21 years after onset, 11 cases associated with monoclonal gammopathy (MCG) were identified and none of the patients had or developed signs of multiple myeloma, malignant plasma cell dyscrasia, macroglobulinemia syndrome, amyloidosis, neoplasia, or other associated illness.
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TLDR
A prevalence as high as that in the series of Osby et al, who found clinical and/or electrophysiological evidence compatible with peripheral polyneuropathy in 15 of 21 patients has not been reported before.
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TLDR
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TLDR
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TLDR
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TLDR
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The electrodiagnostic findings in 51 patients with monoclonal serum proteins of different etiologies and peripheral neuropathies are analyzed and the findings in an additional 10 patients with…
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TLDR
Peripheral neuropathy has been reported in patients with IgG or IgA monoclonal gammopathies in the absence of multiple myeloma, lymphoma, or leukemia, suggesting that similar mechanisms may be involved.
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