Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies

@article{NobileOrazio1992PeripheralNI,
  title={Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies},
  author={Eduardo Nobile‐Orazio and Sergio Barbieri and Luca Baldini and Paola Marmiroli and Marinella Carpo and S. Premoselli and Emanuela Manfredini and Guglielmo Scarlato},
  journal={Acta Neurologica Scandinavica},
  year={1992},
  volume={85}
}
In an unselected series of patients with monoclonal gammopathy of undetermined significance (MGUS) we found neuropathy in 2 of 34 patients with IgG (6%), 2 of 14 with IgA (14%), and 8 of 26 with IgM MGUS (31%). The neuropathy was subclinical in 6 patients (1 IgG, 1 IgA, and 4 IgM). Patients with IgG or IgA MGUS had a prominent motor impairment with electrophysiologic and morphologic findings suggestive of predominant axonal degeneration. No deposit of the M‐protein in sural nerve and no… 
Axonal neuropathy associated with monoclonal gammopathy of undetermined significance
  • K. Gorson, A. Ropper
  • Medicine, Psychology
    Journal of neurology, neurosurgery, and psychiatry
  • 1997
TLDR
There is an axonal neuropathy associated with MGUS that is clinically and electrophysiologically distinct from the more typical demyelinating pattern.
Severe mononeuritis multiplex after rituximab in IgM‐κ monoclonal gammopathy
TLDR
A case of mild axonal sensory neuropathy associated with anti–MAG-negative IgM-j-MGUS that progressed to severe mononeuritis multiplex in the setting of accelerated immune complex deposition after rituximab is reported.
Polyneuropathy associated with IgG/IgA monoclonal gammopathy: a clinical and electrophysiological study of 15 cases
TLDR
Clinical and electrophysiological studies clearly showed that the demyelinating pattern was more heterogeneous in IgG/IgA‐DP than in IgM‐DP, which is similar to classic CIDP, and axonal polyneuropathy, in which the pathogenic role of the MG remains elusive.
Clinical Spectrum and Evolution of Monoclonal Gammopathy-associated Neuropathy: An Observational Study
TLDR
Most of PPN often present a relatively monomorphic clinical picture but they can be clinically heterogenous and must be suspected even if sensory impairment and demyelination are not the dominant features.
Are neurological complications of monoclonal gammopathy of undetermined significance underestimated?
TLDR
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignancy preceding multiple myeloma (MM) or related disorders and should be monitored carefully and referred to a specialized center if neurological symptoms occur.
Neuropathies associated with monoclonal gammopathies
Frequency and clinical correlates of anti–neural IgM antibodies in neuropathy associated with IgM monoclonal gammopathy
TLDR
The frequent occurrence of anti–neural IgM antibodies in neuropathy associated with IgM gammopathy, and their frequent, though not constant association with similar neuropathy features, support their possible pathogenetic role in the neuropathy.
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References

SHOWING 1-10 OF 50 REFERENCES
Peripheral Neuropathy Associated with Monoclonal Gammopathy. Studies of Intraneural Injections of Monoclonal Immunoglobulin Sera
TLDR
Three patients with chronic sensorimotor polyneuropathy associated with plasma cell dyscrasia and monoclonal gammopathies and patients' serum was injected intraneurally into rat sciatic nerves to investigate the role the paraproteins might play in the pathogenesis of the neuropathy, and studies employing an in vivo bioassay technique failed to establish antimyelin activity of monOClonal immunoglobulin sera.
Peripheral neuropathy and anti-MAG antibodies.
TLDR
Recent advances have been made in characterizing the autoantibody activity of M-proteins and correlating antigenic specificity with the type of neuropathy present, in elucidating the effector mechanisms responsible for causing nerve injury, and in understanding the causes for the aberrant immune response.
Polyneuropathy with monoclonal gammopathy: Studies of 11 patients
TLDR
Among patients with chronic idiopathic nonfamilial polyneuropathy studied 3 to 21 years after onset, 11 cases associated with monoclonal gammopathy (MCG) were identified and none of the patients had or developed signs of multiple myeloma, malignant plasma cell dyscrasia, macroglobulinemia syndrome, amyloidosis, neoplasia, or other associated illness.
Peripheral polyneuropathy and monoclonal gammopathy of undetermined significance.
TLDR
A prevalence as high as that in the series of Osby et al, who found clinical and/or electrophysiological evidence compatible with peripheral polyneuropathy in 15 of 21 patients has not been reported before.
Benign monoclonal gammopathy and peripheral neuropathy
TLDR
The benign form of plasma cell dyscrasias seems also to be associated with mild clinical or subclinical peripheral neuropathy, and there were no significant differences in haematological parameters between the two groups with and without clinical neuropathy.
Anti–myelin‐associated glycoprotein IgM antibody titers in neuropathy associated with macroglobulinemia
TLDR
The presence of low levels of anti‐MAG IgM in a significant proportion of controls suggests that monoclonal expansion of naturally occurring B‐cell clones secreting anti‐ MAG IgM may be responsible for the high incidence of this antigen specificity of the M‐protein.
Peripheral neuropathy in macroglobulinemia
TLDR
Peripheral neuropathy was found in 12 (46%) of 26 patients with macroglobulinemia and anti-myelin-associated glycoprotein activity was found six (50%) of patients with neuropathy, suggesting that peripheral neuropathy may be related to the antigen-specificity of M proteins.
Immunofluorescence study of patients with neuropathy and IgM M proteins
TLDR
The findings suggest that IgM M proteins may cause the neuropathy and that more than one autoantigen is involved.
The electrodiagnostic findings in peripheral neuropathy associated with monoclonal gammopathy
The electrodiagnostic findings in 51 patients with monoclonal serum proteins of different etiologies and peripheral neuropathies are analyzed and the findings in an additional 10 patients with
Nonmaligmant IgG and IgA Gammopathies
TLDR
Peripheral neuropathy has been reported in patients with IgG or IgA monoclonal gammopathies in the absence of multiple myeloma, lymphoma, or leukemia, suggesting that similar mechanisms may be involved.
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