Peripheral neuropathy and microangiopathy in rats with insulinoma: association with chronic hyperinsulinemia.

Abstract

BACKGROUND Hypoglycemia can precipitate or worsen peripheral neuropathy in patients with insulinoma or in diabetic patients on an intensive insulin regimen. It still remains unclear as to whether hyperinsulinemia itself is involved in neuropathic changes in these patients. We, therefore, explored the possible isolated effects of chronic hyperinsulinemia on… (More)

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