Peripheral nervous system insulin resistance in ob/ob mice

  title={Peripheral nervous system insulin resistance in ob/ob mice},
  author={Caleb W. Grote and Anna L Groover and Janelle M. Ryals and Paige C Geiger and Eva L. Feldman and Douglas E Wright},
  booktitle={Acta neuropathologica communications},
BACKGROUND A reduction in peripheral nervous system (PNS) insulin signaling is a proposed mechanism that may contribute to sensory neuron dysfunction and diabetic neuropathy. Neuronal insulin resistance is associated with several neurological disorders and recent evidence has indicated that dorsal root ganglion (DRG) neurons in primary culture display altered insulin signaling, yet in vivo results are lacking. Here, experiments were performed to test the hypothesis that the PNS of insulin… CONTINUE READING
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