Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats.

@article{Mimura2004PeripheralNR,
  title={Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats.},
  author={Toshiro Mimura and Mari Dezawa and Hiroshi Kanno and Hajime Sawada and Isao Yamamoto},
  journal={Journal of neurosurgery},
  year={2004},
  volume={101 5},
  pages={806-12}
}
OBJECT Bone marrow stromal cells (BMSCs) can be induced to form Schwann cells by sequentially treating the cells with beta-mercaptoethanol and retinoic acid, followed by forskolin and neurotrophic factors including heregulin. In this study the authors made artificial grafts filled with BMSC-derived Schwann cells (BMSC-DSCs) and transplanted them into the transected sciatic nerve in adult rats to evaluate the potential of BMSCs as a novel alternative method of peripheral nerve regeneration… CONTINUE READING