Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord

@article{Inquimbert2012PeripheralNI,
  title={Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord},
  author={Perrine Inquimbert and Karsten Bartels and Olusegun B. Babaniyi and Lee B. Barrett and Joachim Scholz},
  journal={PAIN®},
  year={2012},
  volume={153},
  pages={2422-2431}
}
Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is critically involved in nociceptive signaling and the development of neuropathic pain. We recorded miniature excitatory postsynaptic currents (mEPSCs) from neurons in lamina II of the… CONTINUE READING

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