Peripheral nerve injury decreases the expression of metabolic glutamate receptor 7 in dorsal root ganglion neurons.

@article{Li2012PeripheralNI,
  title={Peripheral nerve injury decreases the expression of metabolic glutamate receptor 7 in dorsal root ganglion neurons.},
  author={Jian-you Li and Xiang Linda Wang and Peng-Tian Ji and Xiong-feng Li and Guo-hua Guan and Xue-Sheng Jiang and G Zhou and Feng Hua and Nan Wang},
  journal={Neuroscience letters},
  year={2012},
  volume={531 1},
  pages={52-6}
}
Group II and III metabolic glutamate receptors (mGluRs) are responsible for the glutamate-mediated postsynaptic excitation of neurons. Previous pharmacological evidences show that activation of mGluR7 could inhibit nociceptive reception. However, the distribution and expression patterns of mGluR7 after peripheral injury remain unclear. Herein we found that mGluR7 was expressed in the rat peptidergic dorsal root ganglion (DRG) neurons and large neurons, but rarely in isolectin B4 positive… CONTINUE READING
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