Peripheral nerve extracellular matrix remodeling in Charcot-Marie-Tooth type I disease

@article{Palumbo2002PeripheralNE,
  title={Peripheral nerve extracellular matrix remodeling in Charcot-Marie-Tooth type I disease},
  author={C. G. G. Palumbo and Roberto Massa and Maria Panico and Antonio di Muzio and Paola Sinibaldi and Giorgio Bernardi and Andrea Modesti},
  journal={Acta Neuropathologica},
  year={2002},
  volume={104},
  pages={287-296}
}
Abstract. Charcot-Marie-Tooth type 1 disease (CMT1) is a group of inherited demyelinating neuropathies caused by mutations in genes expressed by myelinating Schwann cells. Rather than demyelination per se, alterations of Schwann cell-axon interactions have been suggested as the main cause of motor-sensory impairment in CMT1 patients. In an attempt to identify molecules that may be involved in such altered interactions, the extracellular matrix (ECM) remodeling occurring in CMT1 sural nerves was… CONTINUE READING
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