Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback.

@article{Mukouyama2005PeripheralNV,
  title={Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback.},
  author={Yoh-Suke Mukouyama and H L Gerber and Napoleone M. A. Ferrara and Chenghua Gu and David J. Anderson},
  journal={Development},
  year={2005},
  volume={132 5},
  pages={941-52}
}
In developing limb skin, peripheral nerves are required for arterial differentiation, and guide the pattern of arterial branching. In vitro experiments suggest that nerve-derived VEGF may be important for arteriogenesis, but its role in vivo remains unclear. Using a series of nerve-specific Cre lines, we show that VEGF derived from sensory neurons, motoneurons and/or Schwann cells is required for arteriogenesis in vivo. Arteriogenesis also requires endothelial expression of NRP1, an artery… CONTINUE READING

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