Peripheral morphine analgesia resistant to tolerance in chronic morphine-treated mice.

Intraplantarly ( morphine showed a peripheral analgesia in experiments to assess the blockade of bradykinin ( nociceptive flexor response in mice. The peripheral morphine analgesia in mice which developed central analgesic tolerance to chronic morphine (10 mg/kg s.c., 5 days), was equivalent to that in vehicle-treated mice in… CONTINUE READING