Peripheral monocytes are functionally altered and invade the CNS in ALS patients

  title={Peripheral monocytes are functionally altered and invade the CNS in ALS patients},
  author={Lisa Zondler and Kathrin M{\"u}ller and Samira Khalaji and Corinna Bliederh{\"a}user and Wolfgang P. Ruf and Veselin Grozdanov and Meinolf Thiemann and Katrin Fundel-Clemes and Axel Freischmidt and Karlheinz Holzmann and Benjamin Strobel and Patrick Weydt and Anke Witting and Dietmar Rudolf Thal and Anika M. Helferich and Bastian Hengerer and Kay-E. Gottschalk and Oliver Hill and Michael Kluge and Albert Christian Ludolph and Karin M. Danzer and Jochen H. Weishaupt},
  journal={Acta Neuropathologica},
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease affecting primarily the upper and lower motor neurons. A common feature of all ALS cases is a well-characterized neuroinflammatory reaction within the central nervous system (CNS). However, much less is known about the role of the peripheral immune system and its interplay with CNS resident immune cells in motor neuron degeneration. Here, we characterized peripheral monocytes in both temporal and spatial… 

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