Peripheral modulation of rat knee joint afferent mechanosensitivity by nociceptin/orphanin FQ.

@article{McDougall2000PeripheralMO,
  title={Peripheral modulation of rat knee joint afferent mechanosensitivity by nociceptin/orphanin FQ.},
  author={Jason J McDougall and Matthias Pawlak and Ulrike Hanesch and Robert F. Schmidt},
  journal={Neuroscience letters},
  year={2000},
  volume={288 2},
  pages={123-6}
}
The peripheral effects of nociceptin were examined in normal and acutely inflamed rat knee joints by analyzing single unit recordings from articular primary afferents in response to normal and extreme rotation of the knee. Bolus close intraarterial injection of nociceptin (0.01, 1 and 100 microM) caused a sensitization of normal and inflamed knee joint afferents in response to movements in the normal working range of the joint. When the joint was hyper-rotated, nociceptin had no significant… CONTINUE READING