Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats.

@article{Maclean2006PeripheralMR,
  title={Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats.},
  author={Paul S Maclean and Janine A. Higgins and Matthew R. Jackman and Ginger C. Johnson and Brooke K. Fleming-Elder and H R Wyatt and Edward L. Melanson and James O Hill},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2006},
  volume={290 6},
  pages={
          R1577-88
        }
}
Weight regain after weight loss is the most significant impediment to long-term weight reduction. We have developed a rodent paradigm that models the process of regain after weight loss, and we have employed both prospective and cross-sectional analyses to characterize the compensatory adaptations to weight reduction that may contribute to the propensity to regain lost weight. Obese rats were fed an energy-restricted (50-60% kcal) low-fat diet that reduced body weight by 14%. This reduced… CONTINUE READING

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