Peripheral mechanisms of pain and analgesia.

  title={Peripheral mechanisms of pain and analgesia.},
  author={Christoph Stein and John David Clark and Uhtaek Oh and Michael R. Vasko and George L. Wilcox and Aaron C Overland and Todd W. Vanderah and R. H. Spencer},
  journal={Brain research reviews},
  volume={60 1},
This review summarizes recent findings on peripheral mechanisms underlying the generation and inhibition of pain. The focus is on events occurring in peripheral injured tissues that lead to the sensitization and excitation of primary afferent neurons, and on the modulation of such mechanisms. Primary afferent neurons are of particular interest from a therapeutic perspective because they are the initial generator of noxious impulses traveling towards relay stations in the spinal cord and the… CONTINUE READING