Peripheral mechanisms of opioid antinociception in inflammation: involvement of cytokines.

@article{Czonkowski1993PeripheralMO,
  title={Peripheral mechanisms of opioid antinociception in inflammation: involvement of cytokines.},
  author={Andrzej Członkowski and Christoph Stein and A. Herz},
  journal={European journal of pharmacology},
  year={1993},
  volume={242 3},
  pages={229-35}
}
It has been shown previously that opioids induce antinociceptive effects at peripheral sites in the presence of inflammatory processes. Besides being elicited by local injection of opioids, such effects can also be obtained by activation of intrinsic opioid mechanisms, e.g. following stress. In the present study the possible role of cytokines in this mechanism was investigated. Unilateral inflammation of the hindpaw of rats was induced by local injection of Freund's complete adjuvant… CONTINUE READING

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