Peripheral mechanisms involved in gastric mucosal protection by intracerebroventricular and intraperitoneal nociceptin in rats.

@article{Polidori2005PeripheralMI,
  title={Peripheral mechanisms involved in gastric mucosal protection by intracerebroventricular and intraperitoneal nociceptin in rats.},
  author={Carlo Polidori and Maurizio Massi and Remo Guerrini and Daniela Grandi and Daniela Lupo and Giuseppina Morini},
  journal={Endocrinology},
  year={2005},
  volume={146 9},
  pages={3861-7}
}
Nociceptin (N/OFQ) exerts multiple effects in the gastrointestinal tract after central or peripheral administration. In the present study, we examined the possible peripheral mechanisms mediating gastric protection by N/OFQ in rats. Gastric mucosal lesions were induced by 50% ethanol (1 ml/rat intragastrically). N/OFQ, administered either intracerebroventricularly (3 microg/rat) or ip (10 microg/kg), significantly reduced macroscopic and histological damage. The protective effect of… CONTINUE READING
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No - ciceptin / orphanin FQ acts as a functional antagonist of corticotropin - releasing factor to inhibit its anorectic effect

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