Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone

@inproceedings{Michailidou2007PeripheralMC,
  title={Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone},
  author={Zoi Michailidou and Anthony P. Coll and Christopher J. Kenyon and Nicholas M Morton and Stephen O'Rahilly and Jonathan R Seckl and Karen E. Chapman},
  booktitle={The Journal of endocrinology},
  year={2007}
}
Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic origin. However, low glucocorticoid levels caused by adrenal insufficiency mitigate against insulin resistance, hyperphagia and fat accretion in Pomc-/- mice. Upon exogenous glucocorticoid replacement, corticosterone-supplemented (CORT) Pomc-/- mice show… CONTINUE READING

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