Peripheral markers of blood-brain barrier damage.

  title={Peripheral markers of blood-brain barrier damage.},
  author={Nicola De Marchi and Marco Cavaglia and V. J. Fazio and Sunil K. Bhudia and Kerri L Hallene and Damir Janigro},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={342 1-2},
Neurological diseases are often associated with cerebrovascular dysfunction and changes in blood-brain barrier (BBB) function. This is important for two seemingly conflicting reasons. On the one hand, a leaky BBB may lead to brain disease by allowing extravasation of cells and molecules normally segregated in the periphery, while on the other hand an intact BBB may hamper drug delivery to the ailing brain. Under both circumstances, it would be desirable to follow closely over time BBB… CONTINUE READING


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