Peripheral lymphocyte 8-OHdG levels correlate with age-associated increase of tissue oxidative DNA damage in Sprague–Dawley rats. Protective effects of caloric restriction

  title={Peripheral lymphocyte 8-OHdG levels correlate with age-associated increase of tissue oxidative DNA damage in Sprague–Dawley rats. Protective effects of caloric restriction},
  author={Federica I Wolf and Silvia Fasanella and Beatrice Tedesco and Gabriella Cavallini and Alessio Donati and Ettore Bergamini and Achille Cittadini},
  journal={Experimental Gerontology},

The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats

In conclusion, carnosine treatment was found to be useful in the decrease of age-related oxidative stress in the liver and non-enzymatic and enzymatic antioxidants did not change in heart and brain of aged rats.

Increase of Urinary 8-OH-dG Levels after Administration of a Vitamin-deficient Diet and a Sweet Beverage

The results indicated that the elevation of oxidative stress could be caused by the prolonged intake of an unbalanced diet, such as a vitamin-deficient diet or one including sweet beverages.

Protein and DNA oxidation in different anatomic regions of rat brain in a mimetic ageing model.

The results obtained from the mimetic ageing model rats showed that various anatomical regions of brain have different susceptibility to oxidative damage of proteins, lipids and DNA.

Effect of Fluoride on the Expression of 8-Hydroxy-2'-Deoxyguanosine in the Blood, Kidney, Liver, and Brain of Rats.

The data suggests that concentration and time of fluoride exposure had a significant effect on 8-OHdG, but the effect patterns of fluoride were different in the tissues, which suggests that the impact of fluorine ion in rat blood, kidney, liver, and brain may be a tissue-specific, as well as a non-monotonic positive correlation.

The effects of physical exercise, caloric diet restriction and antioxidant supplementation on the aging process in rats

The aging process was associated with significantly increased serum MDA, decreased hepatic SOD activity, increased brain DNA fragmentation and caspase-3 activation as well as decreased cytochrome c reductase activity of liver and it is suggested that the age-induced oxidative stress, DNA damage and improper hepatic metabolism could be partially attenuated by exercise, CR, and/or vitamin E supplementation.

SURVEY AND SUMMARY Caloric restriction and genomic stability

The majority of studies performed indicate that the age-related increase in oxidative damage to DNA is significantly reduced by CR, and early studies suggest that CR reduces DNA damage by enhancing DNA repair.

Oxidatively damaged DNA in aging dyslipidemic ApoE-/- and wild-type mice.

The results of this study suggest that dyslipidemic ApoE(-/-) mice suffer from hepatic oxidative stress in terms of oxidized DNA, and this effect could be due to the dysfunction of lipid metabolism.

Effects of exercise training on hepatic oxidative stress and antioxidant status in aged rats

It is indicated that exercise training prevents aging-induced hepatic oxidative damage especially in the proteins.



Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

The results suggest that the age-dependent accumulation of oh8dG residues observed in DNA from liver, kidney, and intestine is principally due to the slow loss of DNA nuclease activity; however, an increase in the rate of oxidative DNA damage cannot be ruled out.

Age and Organ Dependent Spontaneous Generation of Nuclear 8-Hydroxydeoxyguanosine in Male Fischer 344 Rats

These findings provide a basis for research dealing with oxidative stress by indicating organ-specific and age- but not aging-dependent changes in the localization of spontaneously generated nuclear 8-OHdG in intact rats.

Does oxidative damage to DNA increase with age?

Dietary restriction was shown to significantly reduce the age-related accumulation of oxo8dG levels in nDNA in all tissues of male B6D23F1 mice and in most tissues ofmale F344 rats, and it was shown that dietary restriction prevented theAge-related increase in oxo 8dG Levels in mtDNA isolated from the livers of both rats and mice.

Changes of 8-hydroxydeoxyguanosine levels in rat organ DNA during the aging process.

The results indicate that the accumulation of oxidative DNA damage during the aging process varies among organs, with slight sex difference.

Caloric Intake, Oxidative Stress and Aging

Transcriptional patterns of calorie-restricted animals suggest that CR retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage and that CR can prevent or retard the establishment of many such gene expression alterations.