Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study.

@article{Furlan1999PeripheralLO,
  title={Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study.},
  author={Roberto Furlan and Massimo Filippi and Alessandra Bergami and M A Rocca and Vittorio Martinelli and P L Poliani and Luigi Grimaldi and G Desina and Giancarlo Comi and Gianvito Martino},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1999},
  volume={67 6},
  pages={785-8}
}
The cysteine protease caspase-1 plays a crucial part in the inflammatory process due to its ability to proteolitically activate proinflammatory cytokine precursors, such as interleukin (IL)-1beta and IL-18. Multiple sclerosis is a chronic inflammatory demyelinating disease of the CNS in which the pathogenic process is mainly orchestrated by proinflammatory cytokines. The role of caspase-1 in multiple sclerosis was evaluated by measuring its mRNA levels in peripheral blood mononuclear cells… CONTINUE READING

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