Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons.

@article{Xu2002PeripheralIS,
  title={Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons.},
  author={G Y Xu and L M Huang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 1},
  pages={93-102}
}
  • G Y Xu, L M Huang
  • Published 2002 in
    The Journal of neuroscience : the official…
ATP-gated P2X receptors in nociceptive sensory neurons participate in transmission of pain signals from the periphery to the spinal cord. To determine the role of P2X receptors under injurious conditions, we examined ATP-evoked responses in dorsal root ganglion (DRG) neurons isolated from rats with peripheral inflammation, induced by injections of complete Freund's adjuvant (CFA) into the hindpaw. Application of ATP induced both fast- and slow-inactivating currents in control and inflamed… CONTINUE READING
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