Peripheral hyperpolarization‐activated cyclic nucleotide‐gated channels contribute to inflammation‐induced hypersensitivity of the rat temporomandibular joint

@article{Hatch2013PeripheralHC,
  title={Peripheral hyperpolarization‐activated cyclic nucleotide‐gated channels contribute to inflammation‐induced hypersensitivity of the rat temporomandibular joint},
  author={Robert J. Hatch and Ernest A. Jennings and Jason J Ivanusic},
  journal={European journal of pain},
  year={2013},
  volume={17 7},
  pages={972-82}
}
BACKGROUND Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels conduct an inward cation current (Ih ) that contributes to the maintenance of neuronal membrane potential and have been implicated in a number of animal models of neuropathic and inflammatory pain. In the current study, we investigated HCN channel involvement in inflammatory pain of the temporomandibular joint (TMJ). METHODS The contribution of HCN channels to inflammation (complete Freund's adjuvant; CFA)-induced… CONTINUE READING

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