Peripheral hyperalgesia in experimental neuropathy: mediation by α2-adrenoreceptors on post-ganglionic sympathetic terminals

@article{Tracey1995PeripheralHI,
  title={Peripheral hyperalgesia in experimental neuropathy: mediation by α2-adrenoreceptors on post-ganglionic sympathetic terminals},
  author={D. Tracey and John E. Cunningham and M A Romm},
  journal={Pain},
  year={1995},
  volume={60},
  pages={317-327}
}
Rats in which the sciatic nerve is partially transected develop hyperalgesia which is relieved by sympathectomy. We carried out experiments using this model of experimental peripheral neuropathy to examine the peripheral mechanisms underlying sympathetically maintained pain. Subcutaneous injection of noradrenaline (NA) into the affected paw exacerbated the hyperalgesia but had no effect in control animals. Injection of the non-specific alpha-adrenergic blocker phentolamine and the alpha 2… CONTINUE READING

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