Peripheral effects of vagus nerve stimulation on anxiety and extinction of conditioned fear in rats.

@article{Noble2019PeripheralEO,
  title={Peripheral effects of vagus nerve stimulation on anxiety and extinction of conditioned fear in rats.},
  author={L. Noble and Ashleigh Chuah and Kathleen K Callahan and R. R. Souza and C. McIntyre},
  journal={Learning \& memory},
  year={2019},
  volume={26 7},
  pages={
          245-251
        }
}
Vagus nerve stimulation (VNS) enhances extinction of conditioned fear in rats. Previous findings support the hypothesis that VNS effects on extinction are due to enhanced consolidation of extinction memories through promotion of plasticity in extinction-related brain pathways however, alternative explanations are plausible. According to one hypothesis, VNS may produce a hedonic effect and enhance extinction through counter-conditioning. According to another hypothesis, VNS reduces anxiety… Expand
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Evidence is provided that VNS can promote generalization of extinction to other stimuli associated with a specific fear experience and the ability to generalize extinction and reduce anxiety makes VNS a potential candidate for use as an adjunctive strategy to improve the efficacy and tolerability of exposure-based therapies. Expand
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Vagus Nerve Stimulation Enhances Extinction of Conditioned Fear in Rats and Modulates Arc Protein, CaMKII, and GluN2B-Containing NMDA Receptors in the Basolateral Amygdala
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