Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease.

@article{Snow1992PeripheralDO,
  title={Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease.},
  author={Alan D. Snow and Henry Yung-Leung Mar and David Nochlin and Hans Kresse and Thomas N Wight},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1992},
  volume={40 1},
  pages={
          105-13
        }
}
We used a polyclonal antibody and a mixture of three monoclonal antibodies (MAb), all recognizing the protein core of the small dermatan sulfate proteoglycan (DSPG) (known as PG-II or decorin) derived from human skin fibroblasts, to immunolocalize this molecule in the characteristic lesions in Alzheimer's brain. All antibodies demonstrated positive decorin immunostaining in both the amyloid deposits of neuritic plaques (NPs) and the filamentous structures within neurofibrillary tangles (NFTs… CONTINUE READING

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