Peripheral development of B cells in mouse and man.

@article{Carsetti2004PeripheralDO,
  title={Peripheral development of B cells in mouse and man.},
  author={Rita Carsetti and Maria Manuela Rosado and Hedda Wardmann},
  journal={Immunological reviews},
  year={2004},
  volume={197},
  pages={179-91}
}
In man and in mouse, B-cell maturation occurs in steps, first in the bone marrow from hematopoietic precursors to immature/transitional B cells, then in the periphery from transitional to fully mature B cells. Each developmental step is tightly controlled by the expression and function of the B-cell receptor (BCR) and by the ability to interact with the microenvironment. Mature B cells collaborate with T cells in the adaptive immune response, leading to the production of high-affinity… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
180 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 180 extracted citations

Similar Papers

Loading similar papers…