Peripheral development of B cells in mouse and man.

  title={Peripheral development of B cells in mouse and man.},
  author={Rita Carsetti and Maria Manuela Rosado and Hedda Wardmann},
  journal={Immunological reviews},
In man and in mouse, B-cell maturation occurs in steps, first in the bone marrow from hematopoietic precursors to immature/transitional B cells, then in the periphery from transitional to fully mature B cells. Each developmental step is tightly controlled by the expression and function of the B-cell receptor (BCR) and by the ability to interact with the microenvironment. Mature B cells collaborate with T cells in the adaptive immune response, leading to the production of high-affinity… CONTINUE READING
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