Peripheral development of B cells in mouse and man

@article{Carsetti2004PeripheralDO,
  title={Peripheral development of B cells in mouse and man},
  author={Rita Carsetti and M. Manuela Rosado and Hedda Wardmann},
  journal={Immunological Reviews},
  year={2004},
  volume={197}
}
Summary:  In man and in mouse, B‐cell maturation occurs in steps, first in the bone marrow from hematopoietic precursors to immature/transitional B cells, then in the periphery from transitional to fully mature B cells. Each developmental step is tightly controlled by the expression and function of the B‐cell receptor (BCR) and by the ability to interact with the microenvironment. Mature B cells collaborate with T cells in the adaptive immune response, leading to the production of high‐affinity… Expand
Human B-Cell Development in a Mouse Environment
TLDR
The kinetics, characteristics, and limitations of human B-cell development in hu-mice are reviewed and what these uniquely translational animal models have taught us about human B -cell biology is summarized. Expand
8 – B-cell development and differentiation
Abstract The establishment of the mature B-cell pool involves a delicate balance that ensures a broad spectrum of specificities and at the same time avoids self-reactivity. B lymphocytes develop fromExpand
Identification and characterization of circulating human transitional B cells.
TLDR
Interestingly, circulating B cells that phenotypically and functionally resemble murine T2 B cells are found in cord blood and adult peripheral blood, suggesting that B-cell maturation may not be restricted to the spleen. Expand
Therapeutic implications of advances in our understanding of transitional B-cell development in humans
TLDR
The latest findings relating to human B cells in health and disease are overviewed with a particular emphasis on the transitional stage of B-cell development. Expand
Somatically Diversified and Proliferating Transitional B Cells: Implications for Peripheral B Cell Homeostasis
TLDR
By neutralizing B cell-activating factor in vivo, this work found an arrest in peripheral B cell development at the T1 B cell stage of adult rabbits, and proposes a model in which these cells develop in GALT, self renew, continuously differentiate into mature B cells, and thereby maintain peripheral Bcell homeostasis in adults in the absence of B lymphopoiesis. Expand
CpG Drives Human Transitional B Cells to Terminal Differentiation and Production of Natural Antibodies
TLDR
The ability of transitional B cells to sense bacterial DNA through TLR9 represents a tool to rapidly build up the repertoire of natural Abs necessary for the first-line defense at birth, as well as proving that IgM memory is the B cell compartment responsible for the defense against encapsulated bacteria. Expand
Marginal Zone B-Cells, a Gatekeeper of Innate Immunity
TLDR
The multiple roles of MZ B-cells in humans, non-human primates, and rodents are discussed and it is revealed that viruses and bacteria have developed strategies to deplete innate-like B- cells during the acute phase of infection and to impair the antibody response. Expand
Clinical consequences of defects in B-cell development.
TLDR
In the secondary lymphoid organs some B cells enter the splenic marginal zone, where preactivated cells lie ready to rapidly respond to T-independent antigens, such as the polysaccharides that coat some microorganisms. Expand
New perspectives in B-1 B cell development and function.
TLDR
Recent experimental data from murine studies supporting the hypothesis that B-1 B cells belong to a developmental lineage distinct from B-2 B cells are highlighted, and attention is drawn to recent studies that have defined new roles for the B- 1a and B1b B-cell subsets in the response to bacteria and self-antigens. Expand
Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond
TLDR
Novel findings regarding the B-cell compartments found in the mouse as a model organism, and in human physiology and pathology are described. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 77 REFERENCES
Baff Mediates Survival of Peripheral Immature B Lymphocytes
TLDR
A model in which excessive BAFF-mediated survival of peripheral immature B cells contributes to the emergence and maturation of autoreactive B cells, skewed towards the MZ compartment is supported, providing new clues on mechanisms regulating B cell maturation and tolerance. Expand
B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals
TLDR
It is shown that selection into the mature pool is an active process and takes place in the spleen, and two populations of splenic B cells were identified as precursors for mature B cells. Expand
Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27
TLDR
Examining the expression of the receptor-type protein tyrosine phosphatase CD148 on human B cells identifies CD148 and CD27 as markers which positively identify memory B cells present in human spleen. Expand
Transitional B cells are the target of negative selection in the B cell compartment
TLDR
The functional and phenotypic division of IgMpos bone marrow B cells in three compartments not only allows to define the target population of physiological processes like negative selection, but will also be a helpful tool for an accurate description of possible developmental blocks in mutant mice. Expand
Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex
TLDR
A mouse mutant that lacks most of the Ig-α cytoplasmic tail exhibits only a small impairment in early B cell development but a severe block in the generation of the peripheral B cell pool, revealing a checkpoint in B cell maturation that ensures the expression of a functional BCR on mature B cells. Expand
Transitional B cells: step by step towards immune competence.
TLDR
Data point to the late transitional B- cell stage as a crucial juncture at which developing B cells gain access to splenic follicles, become responsive to T-cell help and lose sensitivity to negative selection, characterizing the immature B-cell response to B- Cell antigen receptor (BCR) signaling in vitro and in vivo. Expand
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.
TLDR
BAFF may enhance humoral immunity in vivo by promoting survival of ISCs via a BCMA-dependent mechanism and have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases. Expand
Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens.
TLDR
Splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response. Expand
Memory B Cells Are Biased Towards Terminal Differentiation: A Strategy That May Prevent Repertoire Freezing
TLDR
The propensity of memory B cells to undergo terminal plasma cell differentiation may explain the extensive extra follicular plasma cell reaction and the limited germinal center reaction observed in vivo after secondary immunizations, which contrast with primary responses in carrier-primed animals. Expand
The changing preference of T and B cells for partners as T‐dependent antibody responses develop
TLDR
Recirculating virgin CD4+ T cells spend their life migrating between the T zones of secondary lymphoid tissues where they screen the surface of interdigitating dendritic cells, and are subsequently involved in the selection of B cell that have mutated their Ig variable‐region genes. Expand
...
1
2
3
4
5
...