Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO(2).

@article{Blain2010PeripheralCD,
  title={Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO(2).},
  author={Gr{\'e}gory M Blain and Curtis A. Smith and Kathleen S Henderson and Jerome A. Dempsey},
  journal={The Journal of physiology},
  year={2010},
  volume={588 Pt 13},
  pages={2455-71}
}
We assessed the contribution of carotid body chemoreceptors to the ventilatory response to specific CNS hypercapnia in eight unanaesthetized, awake dogs. We denervated one carotid body (CB) and used extracorporeal blood perfusion of the reversibly isolated remaining CB to maintain normal CB blood gases (normoxic, normocapnic perfusate), to inhibit (hyperoxic, hypocapnic perfusate) or to stimulate (hypoxic, normocapnic perfusate) the CB chemoreflex, while the systemic circulation, and therefore… CONTINUE READING