Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease.

@article{Reale2008PeripheralCR,
  title={Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease.},
  author={Marcella Reale and Carla Iarlori and Claudio Feliciani and Domenico Gambi},
  journal={Journal of Alzheimer's disease : JAD},
  year={2008},
  volume={14 2},
  pages={147-59}
}
Cerebral inflammation as well as systemic immunological alterations has been reported in Alzheimer's disease (AD). We aimed to determine whether spontaneous and mitogen stimulated production of peripheral blood mononuclear cell (PBMC) cytokines, chemokines and chemokine receptors in clinically diagnosed patients with AD were unregulated. PBMC were purified from AD patients and from healthy controls. Supernatants were analyzed for cytokine levels by ELISA methods. mRNA expression was determined… CONTINUE READING