Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.

@article{Gangadharan2011PeripheralCA,
  title={Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.},
  author={Vijayan Gangadharan and Rui Wang and Bettina Ulzh{\"o}fer and Ceng Luo and Rita Bardoni and Kiran Kumar Bali and Nitin Agarwal and Irmgard Tegeder and Ullrich Hildebrandt and Gergely Gyorgy Nagy and Andrew J Todd and Alessia Ghirri and Annette H{\"a}ussler and Rolf Sprengel and P. H. Seeburg and Amy B Macdermott and Gary R Lewin and Rohini Kuner},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 4},
  pages={1608-23}
}
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type (AMPA-type) glutamate receptors (AMPARs) play an important role in plasticity at central synapses. Although there is anatomical evidence for AMPAR expression in the peripheral nervous system, the functional role of such receptors in vivo is not clear. To address this issue, we generated mice specifically lacking either of the key AMPAR subunits, GluA1 or GluA2, in peripheral, pain-sensing neurons (nociceptors), while preserving… CONTINUE READING