Corpus ID: 10723584

Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12.

@article{Mortarini2000PeripheralBO,
  title={Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12.},
  author={R. Mortarini and A. Borri and G. Tragni and I. Bersani and C. Vegetti and E. Bajetta and S. Pilotti and V. Cerundolo and A. Anichini},
  journal={Cancer research},
  year={2000},
  volume={60 13},
  pages={
          3559-68
        }
}
Systemic effects on T-cell-mediated antitumor immunity, on expression of T-cell adhesion/homing receptors, and on the promotion of T-cell infiltration of neoplastic tissue may represent key steps for the efficacy of immunological therapies of cancer. In this study, we investigated whether these processes can be promoted by s.c. administration of low-dose (0.5 microg/kg) recombinant human interleukin-12 (rHuIL-12) to metastatic melanoma patients. A striking burst of HLA-restricted CTL precursors… Expand
103 Citations

Paper Mentions

Interventional Clinical Trial
Background: - The experimental drug NHS-IL12 may help the immune system become more active and kill cancer cells that have not responded to standard treatments. NHS-IL12 has… Expand
ConditionsEpithelial Neoplasms, Malignant, Epithelial Tumors, Malignant, Malignant Mesenchymal Tumor
InterventionDrug
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Interleukin-12 and Cancer Therapy
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References

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Characterization of a novel subset of CD8(+) T cells that expands in patients receiving interleukin-12.
Antitumor and antimetastatic activity of interleukin 12 against murine tumors
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