Peripheral blood mononuclear cells represent a reservoir of bovine papillomavirus DNA in sarcoid-affected equines.

@article{Brandt2008PeripheralBM,
  title={Peripheral blood mononuclear cells represent a reservoir of bovine papillomavirus DNA in sarcoid-affected equines.},
  author={Sabine Brandt and Rhea Haralambus and A Schoster and Reinhard Kirnbauer and Christian Stanek},
  journal={The Journal of general virology},
  year={2008},
  volume={89 Pt 6},
  pages={1390-5}
}
Bovine papillomaviruses of types 1 and 2 (BPV-1 and -2) chiefly contribute to equine sarcoid pathogenesis. However, the mode of virus transmission and the presence of latent infections are largely unknown. This study established a PCR protocol allowing detection of <or=10 copies of the BPV-1/-2 genes E5 and L1. Subsequent screening of peripheral blood mononuclear cell (PBMC) DNA derived from horses with and without BPV-1/2-induced skin lesions demonstrated the exclusive presence of E5, but not… CONTINUE READING