Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro.

@article{Iikura2011PeripheralBM,
  title={Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro.},
  author={Katsuhito Iikura and Toshio Katsunuma and Shizuko Saika and Saburo Saito and Sadato Ichinohe and Hiroyuki Ida and Hirohisa Saito and Kenji Matsumoto},
  journal={International archives of allergy and immunology},
  year={2011},
  volume={155 Suppl 1},
  pages={27-33}
}
BACKGROUND Asthmatic patients have a higher susceptibility to rhinovirus (RV) infection, and impaired IFN-β and IFN-λ production has been demonstrated in bronchial epithelial cells from asthmatic adults upon exposure to RV. However, the mechanisms underlying the increased susceptibility of asthmatic patients to RV infection remain poorly understood. The present study aimed to elucidate the characteristics of the immune responses of asthmatic patients' peripheral blood mononuclear cells (PBMCs… CONTINUE READING
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