Peripheral blood mononuclear cells from mild cognitive impairment patients show deregulation of Bax and Sod1 mRNAs.

@article{Gatta2009PeripheralBM,
  title={Peripheral blood mononuclear cells from mild cognitive impairment patients show deregulation of Bax and Sod1 mRNAs.},
  author={Lucia Gatta and Alessio Cardinale and Francesca Wannenes and Claudia Consoli and Andrea Armani and Francesca Molinari and Caterina Mammi and Fabrizio Stocchi and Margherita Torti and Giuseppe M. C. Rosano and Massimo Fini},
  journal={Neuroscience letters},
  year={2009},
  volume={453 1},
  pages={36-40}
}
Elevated oxidative stress-induced apoptosis has been found in peripheral cells from patients with Alzheimer's disease (AD). Furthermore, treatment of lymphocytes from AD patients, with Abeta(1-42) and H(2)O(2) results in enhanced apoptosis. Mild cognitive impairment (MCI), a clinical condition between normal aging and AD, shares with AD a similar pattern of peripheral markers of oxidative stress. In this study we investigated spontaneous and H(2)O(2)-induced oxidative stress and apoptosis… CONTINUE READING