Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB<ce:sup loc=post>−/−</ce:sup> mouse model of neurodegeneration

@article{Kyrkanides2008PeripheralBM,
  title={Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB<ce:sup loc=post>−/−</ce:sup> mouse model of neurodegeneration},
  author={Stephanos Kyrkanides and A. Woodruff Miller and Jen-nie H. Miller and Ross Tallents and John A. Olschowka},
  journal={Journal of Neuroimmunology},
  year={2008},
  volume={203},
  pages={50-57}
}
Myeloid-derived immune cells, including microglia, macrophages and monocytes, have been previously implicated in neurodegeneration. We investigated the role of infiltrating peripheral blood mononuclear cells (PBMC) in neuroinflammation and neurodegeneration in the HexB-/- mouse model of Sandhoff disease. Ablation of the chemokine receptor CCR2 in the HexB-/- mouse resulted in significant inhibition of PBMC infiltration into the brain, decrease in TNFalpha and MHC-II mRNA abundance and… CONTINUE READING

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