Peripheral blood-derived, γ9δ2 t cell-enriched cell lines from glioblastoma multiforme patients exert anti-tumoral effects in vitro.

@article{MarcuMalina2016PeripheralB,
  title={Peripheral blood-derived, γ9δ2 t cell-enriched cell lines from glioblastoma multiforme patients exert anti-tumoral effects in vitro.},
  author={Victoria Marcu-Malina and Daniela Garelick and Naama Peshes-Yeloz and Anton Wohl and Lior Zach and Meital Nagar and Ninette Amariglio and Michal J Besser and Z R Cohen and Ilan Bank},
  journal={Journal of biological regulators and homeostatic agents},
  year={2016},
  volume={30 1},
  pages={
          17-30
        }
}
The goal of this work was to assess the potential of T cells expressing Vγ9Vδ2+ T cell receptors (TCR, γ9δ2T cells) present in peripheral blood (PB) m ononuclear cells (MC, PBMC) of glioblastoma multiforme (GBM) patients to act as anti-tumoral agents. We found that γ9δ2T cell levels were decreased in patients' PB relative to a cohort of healthy donors (HD) (respectively 0.52±0.55%, n=16, vs 1.12±0.6%, n=14, p=0.008) but did not significantly correlate with postoperative survival (R=0.6, p=0.063… CONTINUE READING
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