Peripheral blood dendritic cells and monocytes are differently regulated in the elderly.

@article{Bella2007PeripheralBD,
  title={Peripheral blood dendritic cells and monocytes are differently regulated in the elderly.},
  author={Silvia Della Bella and Luigi Bierti and Pietro Presicce and Rossana Arienti and Marta Valenti and Marina Saresella and Carlo Vergani and Maria Luisa Villa},
  journal={Clinical immunology},
  year={2007},
  volume={122 2},
  pages={220-8}
}
Dendritic cells (DCs) are the single most central player in all immune responses. To assess whether DC alterations may contribute to the immune dysregulation that affects the elderly, we investigated the effects of ageing on DCs. We analyzed the number, phenotype and function of peripheral blood DCs from 70 healthy subjects aged 20-92 years by using flow cytometric methods that allow cell characterization directly in whole blood samples. We demonstrated that the number of myeloid DCs… CONTINUE READING