Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma.

@article{Spears2011PeripheralBD,
  title={Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma.},
  author={Mark Spears and Charles P McSharry and Iona Donnelly and Lisa Jolly and Maureen Brannigan and Jessica Thomson and Jane Lafferty and Rekha Chaudhuri and Malcolm Shepherd and Euan Cameron and N C Thomson},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2011},
  volume={41 5},
  pages={665-72}
}
BACKGROUND Dendritic cells (DCs) are crucial for the processing of antigens, T lymphocyte priming and the development of asthma and allergy. Smokers with asthma display altered therapeutic behaviour and a reduction in endobronchial DC CD83 expression compared with non-smokers with asthma. No information is available on the impact of smoking on peripheral blood DC profiles. OBJECTIVE Determine peripheral blood DC profiles in subjects with and without asthma with differing smoking histories… CONTINUE READING